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pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May well lead to lack of virologic reaction and probable resistance.pentobarbital will decrease the extent or outcome of fosamprenavir by impacting hepatic/intestinal enzyme CYP3A4 metabolis